view:41424 Last Update: 2024-1-30
فارسی
English|
Ebrahim Ahmadi, Ali Ramazani,* and Mehdi Nekomanesh Haghighi
A novel four-component reaction of diethylamine, an aromatic aldehyde and an alkyl isocyanide with dialkyl acetylenedicarboxylates in the presence of silica gel: an efficient route for the regio- and stereoselective synthesis of sterically congested alkenes |
The 1:1 intermediate generated by the addition of an isocyanide to a dialkyl acetylenedicarboxylate is trapped by the iminium ion intermediate that forms from the reaction between an aromatic aldehyde and diethylamine. The reactions were completed in the presence of silica gel powder. The product dialkyl 2-[(alkylamino)carbonyl]-3-[(Z)-1-(diethylamino)-1-arylmethylidene] succinates, were produced in acceptable yields. The reactions are completely regio- and stereoselective. |