Abstract

Oxidised copper nanoparticles on TiO2 have been found to effectively catalyze the multicomponent synthesis of 1,4-disubstituted 1,2,3-triazoles in water under both conventional heating and ultrasonic irradiation conditions. The Cu/TiO2 nanocatalyst is easy to prepare, very versatile and recyclable. Following the optimized conditions, an array of 1,2,3-triazoles containing thiazolidine-2-thiones were synthesized from 5- iodomethylthiazolidine-2-thiones, sodium azide, and phenylacetylene. All the compounds were evaluated for antibacterial activitiy and some of them displayed varying levels of antibacterial activity against Staphylococcus aureus and Escherichia coli.