چکيده

Early obesity and its transfer to the adulthood, increases likelihood incidence of coronary artery disease (CAD). ATP-binding cassette transporter (ABCA1) as a member of the ABC transporters family plays a crucial role in reverse cholesterol transport and CAD prevention. The purpose of this study was to investigate ABCA1 expression in lymphocytes, plasma apolipoprotein A-I and HDL-C in response to eight weeks interval aerobic endurance exercise (IERT) in overweight and obese boy adolescents(OAOBA). Thirty students (17.3±1.1yr, 85.73± 11.68 kg and 28.41± 2.36 kg / m²) volunteered and randomly were assigned into training(n = 15) and control (n =15) groups . Exercise protocol was IERT(8 wk, 4 d/wk and 40 min/d).Cell hemolysis and sensitive Elisa method was used for Lymphocyte ABAC1 protein expression.T-student test was employed and data were analyzed by SPSS software (version 16). The independent-samples T-Test results were showed that after 8 weeks IERT, the levels of lymphocyte ABCA1 expression(p=0/000) and VO2max(p=0/000) were significantly increased and plasma levels of TG(p=0.017), TC(p=0.001), LDL-c/HDL-c(p=0.026),TC/HDL-c(p=0.002) and measures of BF%(p=0/015)and BMI(p=0.042) as anthropometric indicators were significantly decreased . Changes of other variables such increasing in Apo A-I, HDL-c, LDL-c and decreasing in body weight, were not significant. (p<0.05) The findings of this study proved that 8-week IERT can be have positive effects on lymphocyte ABCA1 protein expression(as goalkeeper of reverse cholesterol process)and lipid profiles and ultimately in prevention of arteriosclerosis among OAOBA. Keywords: ABCA1, ApoA-I, HDL-C, interval endurance training, overweight and obese boy adolescents