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Mohaddeseh Ebrahimi-Ghiri

Mohammad Reza Zarrindast, Morteza Piri, Mohammad Nasehi, Mohaddeseh Ebrahimi-Ghiri
Nitric oxide in the nucleus accumbens is involved in retrieval of inhibitory avoidance memory by nicotine
نیتریک اکساید در هسته آکومبنس در برگشت حافظه اجتنابی مهاری توسط نیکوتین دخالت دارد

In the present study, the possible effect of nitric oxide agents injected into the nucleus accumbens (NAc) in the presence or absence of nicotine on morphine state-dependent memory in adult male Wistar rats was investigat-ed. As a model of memory, a step-through type inhibitory avoidance task was used. Post-training injection of morphine (4 and 6 mg/kg) dose dependently induced the impairment of memory retention. Administration of morphine (4 and 6 mg/kg) before retention induced state-dependent retrieval of the memory acquired under post-training morphine (6 mg/kg) influence. Injection of nicotine before retention (0.25 and 0.5 mg/kg) alone and nicotine (0.1, 0.25 and 0.5 mg/kg) plus an ineffective dose of morphine (2 mg/kg) reversed the post-training morphine-induced memory impairment. The amnesia elicited by morphine (6 mg/kg) was also prevented by pre-retention intra-NAc administration of a nitric oxide synthase (NOS) inhibitor, L-NAME (0.24 μg/rat, intra-NAc). Interestingly, an ineffective dose of nicotine (0.1 mg/kg) in combination with low doses of L-NAME (0.06 and 0.12μg/rat, intra-NAc) synergistically improved memory performance impaired by morphine given after training. It is important to note that intra-NAc administration ofL- N A M E b e f ore r et en ti on impaired memory retrieval by itself. In contrast, pre-retention administration of L-arginine, a nitric oxide (NO) precursor (0.25 and 0.5 μg/rat, intra-NAc), which had no effect alone, prevented the nicotine reversal of mor-phine effect on memory. The results suggest a possible role for nitric oxide of nucleus accumbens in the improv-ing effect of nicotine on the morphine-induced amnesia and morphine state-dependent memory.



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