Home :: Academic Members :: News

view:21606   Last Update: 2019-1-30

Nader NoshiranZadeh

Parvaneh Pakravan ;  Ali  Ramazani;  Nader Noshiranzadeh ; Alireza Sedrpoushan
One-Pot Synthesis of Fluorine-Containing Alkenes from In Situ-Generated Stabilized Phosphorus Ylides

Protonation of the highly reactive 1:1 intermediates, produced in the reaction between triphenylphosphine and dialkyl acetylenedicarboxylates, by 4- (trifluoromethyl)benzyl alcohol leads to vinyltriphenylphosphonium salts, which undergo a Michael addition reaction with a conjugate base to produce the corresponding fluorine-containing stabilized phosphorus ylides. An intermolecular Wittig reaction of the fluorine-containing stabilized phosphorus ylides with ninhydrin leads to the corresponding highly electron-poor fluorine-containing alkenes.



Copyright © 2020, University of Zanjan, Zanjan, Iran